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KMID : 0356620110260010092
Journal of Korean Society of Endocrinology
2011 Volume.26 No. 1 p.92 ~ p.96
Successful Localization of Distant Metastasis in Parathyroid Carcinoma Using Intraoperative Parathyroid Hormone Assay
Hong Ho-Cheol

Kim Sun-Won
Kim Tae-Hyung
Cha In-Hye
Ahn Jae-Hee
Yoo Hye-Jin
Kim Hee-Young
Seo Ji-A
Kim Hyun-Koo
Kim Sin-Gon
Kim Nan-Hee
Choi Kyung-Mook
Lee Jae-Bok
Baik Sei-Hyun
Choi Dong-Seop
Abstract
Intra-operative parathyroid hormone (IOPTH) assay is a useful tool to confirm complete excision of all hyper-functioning parathyroid gland tissue. In this report, we describe a case with successful localization of distant metastasis in a patient with parathyroid carcinoma using the IOPTH assay. A 53-year-old man presented to our clinic with a serum calcium level of 11.8 mg/dL and an intact PTH level of 233.3 pg/mL. He had been treated for parathyroid carcinoma eleven years ago. Two suspected metastatic lesions were detected on the chest computed tomography. Due to the vastly different surgical field necessary to excise each lesion, we preferentially removed only one lesion and we monitored the other remaining suspected lesion without resection via IOPTH assay. Six months later, the patient¡¯s serum calcium and intact PTH levels remained within their normal ranges. To the best of our knowledge, this is the first case to effectively utilize IOPTH assay for the management of metastatic parathyroid carcinoma.
KEYWORD
Intra-operative parathyroid hormone assay, Parathyroid carcinoma
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